ea0019p127 | Diabetes, Metabolism and Cardiovascular | SFEBES2009
Bogdarina Irina
, King Peter
, Langley-Evans Simon
, Clark Adrian
We recently demonstrated that fetal programming changes induced by a maternal low protein diet (MLP) that lead to the development of hypertension in the rat offspring were associated with increased expression of the AT1b angiotensin receptor (AT1b) and reduced methylation of its promoter in the adrenal gland. Previous findings have suggested that overactivity of the maternal pituitary–adrenal axis in pregnancy results in overexposure of the fetus to glucocorticoids which ...